Status:
COMPLETED
Study on the Effect of a Beta Blocker on Increased Sensitivity to Pain in Humans Caused by Opioids
Lead Sponsor:
Stanford University
Conditions:
Hyperalgesia
Eligibility:
MALE
18-45 years
Phase:
PHASE2
Brief Summary
This research study explores whether a beta-blocker (propranolol) can prevent a person from becoming more sensitive to pain after administration of an opioid (remifentanil). Beta blockers inhibit the ...
Detailed Description
Recent evidence suggests that opioid therapy may cause a biphasic response, i.e. initial pain relief followed paradoxically by a longer lasting hypersensitivity to pain. Recent genetic analysis in mic...
Eligibility Criteria
Inclusion
- Healthy men,
- Age between 18 and 45 years
- Normal weight (according to the table provided by Metropolitan Life Insurance).
Exclusion
- Hypersensitivity to opioids or naloxone,
- History of addictive disease,
- Significant cardiac, respiratory, gastrointestinal, neurological, dermatological, and psychiatric diseases,
- Concurrent medication with an analgesic drug,
- Student and employees affiliated with our laboratory
Key Trial Info
Start Date :
February 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2011
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT01222091
Start Date
February 1 2009
End Date
June 1 2011
Last Update
June 15 2018
Active Locations (1)
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1
Stanford University School of Medicine
Stanford, California, United States, 94305