Status:
COMPLETED
Absorptive Clearance After Inhaled Osmotics in Cystic Fibrosis
Lead Sponsor:
University of Pittsburgh
Conditions:
Cystic Fibrosis
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
Blockage of the breathing tubes of the lungs by thick, sticky mucus is a major cause of lung problems for people with cystic fibrosis (CF). Many researchers now believe that people with CF absorb too ...
Detailed Description
There is a substantial need for new biomarkers in the study of cystic fibrosis (CF) lung disease. Conventional endpoints, such as rate of FEV1 decline, require prolonged trials and large sample sizes ...
Eligibility Criteria
Inclusion
- age ≥ 18 years
- diagnosis of cystic fibrosis as determined by sweat test or genotype and clinical symptoms
- clinically stable as determined by the investigator (pulmonologist)
Exclusion
- intolerant to hypertonic saline.
- FEV1%p \<40% of predicted
- nursing mother
- positive urine pregnancy test
- unwilling to stop hypertonic saline therapy for 72 hours prior to each test day
- cigarette smoker (regular smoking within 6 months of study)
Key Trial Info
Start Date :
September 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2012
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT01223183
Start Date
September 1 2010
End Date
December 1 2012
Last Update
November 29 2018
Active Locations (1)
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1
University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15213