Status:
COMPLETED
Myeloid Suppressors in Inflammation
Lead Sponsor:
University of South Florida
Conditions:
Asthma
Eligibility:
All Genders
18-60 years
Brief Summary
Myeloid-derived suppressor cells (MDSC) have been studied for their ability to suppress T cell responses in vivo and in vitro. As a result, MDSC can regulate cellular responses to chronic inflammatory...
Eligibility Criteria
Inclusion
- Inclusion
- Ages eligible for study: 18 to 60 years
- Genders eligible for study: male and female
- Signed and dated written informed consent is obtained prior to study blood draw.
- Subjects being actively treated for chronic moderate to severe asthma based on National Heart Lung and Blood Institute guidelines (figure 1). Subjects must carry the diagnosis of asthma (made by a physician) for a minimum of six months.
- Subjects within the first seven days of an acute asthma exacerbation, as determined by the referring physician.
- Able to give informed consent.
- Exclusion Criteria:
- Use of systemic corticosteroids within the previous two weeks.
- Pregnant and/or lactating females.
- Current tobacco use.
- Severe psychiatric illness.
- Current illicit substance abuse or dependence and/or abuse of alcohol.
- Current use of anti-microbial medications.
- Primary or secondary immunodeficiency.
- Any clinically significant uncontrolled medical condition that would put the patient's safety at risk.
Exclusion
Key Trial Info
Start Date :
October 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 1 2012
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT01224223
Start Date
October 1 2010
End Date
January 1 2012
Last Update
June 28 2012
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
USF Asthma, Allergy and Immunology CRU
Tampa, Florida, United States, 33613