Status:
COMPLETED
Corticosteroids in Community Acquired Pneumonea
Lead Sponsor:
Cairo University
Conditions:
Community Acquired Pneumonia
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Low dose hydrocortisone IV in patients with CAP fastens recovery of pneumonia and prevents the development of sepsis related complications with a significant reduction in duration of mechanical ventil...
Detailed Description
Inclusion Criteria Minor criteria includes * respiratory rate \> 30 bpm at admission; * ratio of PaO2 to fraction of inspired oxygen (PaO2:FIO2 ) \< 250; * chest radiograph showing bilateral involvem...
Eligibility Criteria
Inclusion
- Minor criteria included
- respiratory rate \> 30 bpm at admission;
- ratio of PaO2 to fraction of inspired oxygen (PaO2:FIO2 ) \< 250;
- chest radiograph showing bilateral involvement or multilobar involvement;
- systolic blood pressure \< 90 mm Hg; or
- diastolic blood pressure \< 60 mm Hg. Major criteria included
- Requirement of MV;
- Increase in the size of opacities on chest radiograph of 50% or more at 48 hours;
- Requirement of vasopressors for more than 4 hours; or
- Serum creatinine 2 mg/dl or more. 10
Exclusion
- Children;
- Nosocomial pneumonia;
- Hospitalisation within the previous 14 days;
- Severe immunosuppression (chronic use of systemic steroids);
- Non-steroid immunosuppressive treatment or HIV);
- Chronic chest disease; , tuberculosis, aspiration or obstructive pneumonia;
- Congestive heart failure (cerebrovascular stroke);
- Chronic renal or hepatic disease;
- Acute burn injury;
- Malignancy;
- Pregnancy; and
- Major gastrointestinal bleed within 3 months of the current hospitalization.
Key Trial Info
Start Date :
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT01228110
Last Update
October 26 2010
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