Status:
COMPLETED
Sympathetic Activity in Patients With End-stage Renal Disease on Peritoneal Dialysis
Lead Sponsor:
Ottawa Hospital Research Institute
Collaborating Sponsors:
Heart and Stroke Foundation of Ontario
Conditions:
End-stage Renal Disease (ESRD)
Kidney Disease
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
Hypothesis: Patients starting peritoneal dialysis with a glucose-based regimen have high sympathetic activity in response to an increase in leptin and insulin. Converting patients from a regimen of o...
Detailed Description
Cardiovascular mortality remains higher among patients treated with peritoneal dialysis as compared to patients treated with hemodialysis. Sympathetic hyperactivity is considered a significant emergin...
Eligibility Criteria
Inclusion
- Adult (age 18 years and older)
- Patients with end-stage renal disease(ESRD)/chronic kidney disease(CKD)stage 5
Exclusion
- Diabetes Mellitus
- Acute coronary syndrome in the past 6 months
- Cardiac arrhythmias (2nd and 3rd degree heart block or premature ventricular complexes in Lown classes 4 or 5)
- Symptoms suggestive of obstructive or central sleep apnea (with a score of \> 10 on Epworth sleepiness scale)
- Patients taking Clonidine
- Body mass index (BMI) \> 34
- Patients unable to give consent
- Pregnant women
- Patients with leg injury involving nerve damage
- Patients taking anticoagulant medication
- Patients with significant bleeding disorder or liver disorder
- Hemoglobin \<1.05 g/dl at the time of initiation of therapy
- patients with unilateral or bilateral nephrectomy
- Planned kidney transplant in the next 4 months
- Life expectancy under 6 months
- Oliguria (urine output less than 400 ml per day)
Key Trial Info
Start Date :
July 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2018
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT01228279
Start Date
July 1 2007
End Date
December 1 2018
Last Update
March 15 2021
Active Locations (1)
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1
Ottawa Hospital Research Institute
Ottawa, Ontario, Canada