Status:
COMPLETED
Free Fatty Acid Induced Insulin Resistance
Lead Sponsor:
German Diabetes Center
Collaborating Sponsors:
Heinrich-Heine University, Duesseldorf
Conditions:
Insulin Resistance
Eligibility:
All Genders
20-55 years
Brief Summary
This study aims to explore time-dependent effects of lipid infusion an intramyocellular lipid metabolites and the induction of impaired insulin signaling.
Detailed Description
Increased availability of free fatty acids impairs glucose disposal in young healthy humans. Patients with type 2 diabetes have reduced whole body glucose disposal, increased ectopic lipid deposition ...
Eligibility Criteria
Inclusion
- non-diabetic (OGTT), no family history of diabetes, BMI\<30 kg/m2, age: 20-55 years, no medication
- For the athletes group additionally:
- VO2max \> 60ml/kg/min for males and VO2max \> 45ml/kg/min for females Active in endurance-exercise activities, 3 times a week for at least 2 years Stable level of training for at least 3 months
Exclusion
- acute illness within the last 2 weeks, autoimmune diseases, renal insufficiency (creatinine\> 1.5 mg/dl), cardiovascular diseases, anemia (Hb\< 12g/l), donation of blood within the last 4 weeks before the study, thyroid diseases, pregnancy, smoking, night-shift working (disturbed circadian rhythm), defective coagulation or wound healing, cancer, allergy against soja products
Key Trial Info
Start Date :
March 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 1 2019
Estimated Enrollment :
55 Patients enrolled
Trial Details
Trial ID
NCT01229059
Start Date
March 1 2010
End Date
November 1 2019
Last Update
August 15 2023
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
German Diabetes Center
Düsseldorf, North Rhine-Westphalia, Germany, 40225