Status:
COMPLETED
Functional Magnetic Resonance Imaging (fMRI) Findings in Children With Early Exposure to General Anesthesia
Lead Sponsor:
Nationwide Children's Hospital
Conditions:
Exposed to Anesthesia
Eligibility:
All Genders
10-17 years
Brief Summary
General anesthetic medications have been shown to cause neuronal cell death in the brains of infant rodents. Ethanol and general anesthetics both act on NMDA and GABA receptors,and appear to have simi...
Eligibility Criteria
Inclusion
- Children ages 10-17 years with an history of exposure to general anesthesia for at least one hour in duration during the ages of 0-24 months of age.
- The cognitive ability to complete fMRI imaging.
- Consent of the subject's guardians and assent of the subject.
- Right hand dominance.
- English language speaker.
Exclusion
- Subjects with known possibility or knowledge of pregnancy.
- Documentation of hemodynamic or respiratory instability documented on the anesthetic record
- Subjects with the inability to complete MRI imaging without sedation.
- History of prenatal ethanol exposure.
- History of exposure to antiepileptic medication.
- History of Attention Deficit Disorder (ADD), or Attention Deficit Hyperactivity Disorder (ADHD)
- History of traumatic brain injury
- History of psychiatric disease or exposure to psychoactive medications.
- History of substance abuse.
Key Trial Info
Start Date :
October 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 1 2011
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT01229514
Start Date
October 1 2008
End Date
June 1 2011
Last Update
August 2 2012
Active Locations (1)
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1
Nationwide Children's Hospital
Columbus, Ohio, United States, 43205