Status:
UNKNOWN
Antiproteinuric Effect of Imidapril Versus Ramipril in Type 2 Diabetic and Hypertensive Patients With Microalbuminuria
Lead Sponsor:
University of Pavia
Conditions:
Hypertension
Type 2 Diabetes Mellitus
Eligibility:
All Genders
18-70 years
Phase:
PHASE3
Brief Summary
Numerous clinical and experimental data show that the elective treatment of diabetic nephropathy should be based on drugs that inhibit the renin-angiotensin system (RAS). Albuminuria is a marker of ri...
Eligibility Criteria
Inclusion
- Blood pressure\> 130/80 ≤ 170/100 mmHg at the end of the period of wash-out
- Type 2 diabetes mellitus well controlled by medication and / or compliance with diet (HbA1c \<7%)
- Microalbuminuria in the upper range of normal (\> 150 \<300 mg/24 h)
Exclusion
- Pregnancy, lactation or women of childbearing age.
- Inability to stop treatment in place for a few days during the wash-out.
- Sitting diastolic blood pressure\> 100 mmHg or systolic pressure\> 170 at the end of the wash-out.
- History of hypertensive encephalopathy or cerebrovascular accident within 12 months prior.
- Secondary hypertension.
- Heart failure
- Acute myocardial infarction; angina pectoris
- Liver and kidney dysfunction
- Known hypersensitivity to ACE inhibitors
- All other physiological or pathological condition that the physician may affect the evaluation of the parameters under study or interfere with the proper conduct of the study.
Key Trial Info
Start Date :
October 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2011
Estimated Enrollment :
206 Patients enrolled
Trial Details
Trial ID
NCT01230034
Start Date
October 1 2010
End Date
July 1 2011
Last Update
October 28 2010
Active Locations (1)
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1
University of Pavia
Pavia, Italy, 27100