Status:
COMPLETED
Study to Monitor the Effects of Androgen Suppression Treatment on the Heart
Lead Sponsor:
Ottawa Heart Institute Research Corporation
Conditions:
Prostate Cancer
Eligibility:
MALE
40-80 years
Phase:
PHASE4
Brief Summary
Suppression of effects of androgens with male sex hormones, androgen suppression treatment (AST), has been known to reduce deaths and prolong life in advanced prostate cancer. There have, however, bee...
Detailed Description
Treatment group: Prior to the initiation of AST, subjects will have a baseline N-13-ammonia PET scan and a brachial artery ultrasound at the University of Ottawa Heart Institute. Blood glucose and a l...
Eligibility Criteria
Inclusion
- Cancer Population:
- Diagnosis of prostate cancer
- Treatment group: Scheduled to start AST, at Ottawa Hospital under the care of Radiation Oncology, Urology or Medical Oncology.
- Control group: no AST scheduled as a treatment option for prostate cancer.
- Non-Cancer Control Group
- Male with low pre-test likelihood of coronary artery disease
- No previous history of cancer.
Exclusion
- Known coronary disease including any of previous revascularization, history of myocardial infarction, coronary disease with \>= 50% stenosis in a major coronary vessel on previous angiography, evidence of previous myocardial infarction on 12-lead electrocardiogram, positive myocardial perfusion scan, previous cardiac PET scan, stress echocardiogram or exercise stress test.
- Subjects with a Summed Stress Score of \>4 attributed to coronary disease on baseline PET images
- Patients previously treated with AST
- Patients with a life expectancy of less than 1 year.
Key Trial Info
Start Date :
July 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2011
Estimated Enrollment :
181 Patients enrolled
Trial Details
Trial ID
NCT01230905
Start Date
July 1 2008
End Date
September 1 2011
Last Update
April 24 2017
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University of Ottawa Heart Institute
Ottawa, Ontario, Canada, K1Y 4W7