Status:
WITHDRAWN
A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study of the Relationship Between Intraoperative Intravenous Acetaminophen and Postoperative Opioid Avoidance for Ambulatory Surgical Procedures
Lead Sponsor:
University of California, San Diego
Collaborating Sponsors:
Cadence Pharmaceuticals
Conditions:
Postoperative Pain
Intraoperative and Postoperative Opioid Requirements
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
This is a research study to determine if giving acetaminophen intravenously in hte operating room will decrease the number of patients who require additional pain medicine, such as morphine, after sur...
Detailed Description
Primary Specific Aim: To determine if adding an intraoperative dose of intravenous acetaminphen to usual and customary analgesics during ambulatory surgery impacts the proportion of patients remaining...
Eligibility Criteria
Inclusion
- Undergoing ambulatory surgery under general anesthesia
- Expected postoperative pain to be mild-moderate
- Age 18 years or older
- Have an ASA physical status or 1, 2, or 3
Exclusion
- Anticipated peripheral or neuraxial nerve block
- Any physical, mental or medical conditions which may confound quantifying postoperative pain resulting from surgery
- Current chronic opioid or tramadol use
- History of alcohol or opioid abuse
- Known allergy to the study medications
- Pregnancy
- Any health condition requiring greater than 100 micrograms of fentanyl during anesthesia induction
- Treated with any acetaminophen-containing medication in the previous 8 hours
- Treated with MAO inhibitors within 10 days prior to surgery
- Inability to communicate with the investigators and hospital staff
- Known or impaired liver function
Key Trial Info
Start Date :
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT01231191
Last Update
March 8 2012
Active Locations (1)
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1
UCSD Medical Center (Hillcrest and Thornton)
San Diego, California, United States, 92103