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Status:

COMPLETED

Isotopic Imaging for Prodromal Alzheimer's Disease

Lead Sponsor:

Centre Hospitalier Universitaire de Nīmes

Conditions:

Alzheimer Disease

Eligibility:

All Genders

70+ years

Brief Summary

The primary objective of this study is to characterize cerebral metabolism modifications using 18F-FDG PET technology and perfusion with 99MTC-ECD SPECT in patients with prodromal Alzheimer's Disease ...

Eligibility Criteria

Inclusion

  • Inclusion Criteria for the group with memory problems:
  • patient consulting for memory problems
  • caucasian
  • memory complaint is validated by a clinical evaluation
  • cognitive performance is sufficiently well preserved so that a diagnostic of dementia cannot be made (according to the DSM-IV-R and NINCDS-ADRDA criteria) at the time of inclusion
  • the patient speaks French
  • presence of an informant
  • accepts to sign consent
  • Inclusion Criteria for the group without memory problems (reference population):
  • at least four years of formal education
  • patient consulting for memory problems
  • memory problem reported by the patient is not validated by the consultation, nor by the battery of tests specified during screening
  • presence of an informant
  • Clinical Dementia Rating (CDR) = 0
  • accepts to sign consent
  • Exclusion Criteria:
  • Instrumental Activities of Daily Living (IADL): at least two items \> 1
  • Anticholinesterasic treatments and/or memantin before study inclusion
  • major depressive syndrome, according to the Global Depressive Scale
  • Known neurodegenerative disease or general disease or major physical problems that could interfere with cognitive functioning and testing
  • Pathology that might lead to death in the short term (evolving cancer, non stable cardiopathy, hepatic, renal or respiratory insufficiency)
  • contra-indications for MRI, PET or SPECT scans
  • not affiliated with a social security regimen

Exclusion

    Key Trial Info

    Start Date :

    February 1 2011

    Trial Type :

    OBSERVATIONAL

    Allocation :

    ACTUAL

    End Date :

    September 1 2016

    Estimated Enrollment :

    143 Patients enrolled

    Trial Details

    Trial ID

    NCT01231295

    Start Date

    February 1 2011

    End Date

    September 1 2016

    Last Update

    February 1 2017

    Active Locations (25)

    Enter a location and click search to find clinical trials sorted by distance.

    Page 1 of 7 (25 locations)

    1

    CHU d'Amiens - Hôpital Sud

    Amiens, France, 80054

    2

    CHU d'Angers - Hôtel-Dieu

    Angers, France, 49933

    3

    CHU de Besançon - Hôpital Jean Minjoz

    Besançon, France, 25030

    4

    CHU de Bordeaux - Groupe Hospitalier Pellegrin

    Bordeaux, France, 33076