Status:
UNKNOWN
Coronary Flow Reserve Evaluation in PET and in MRI Scanner in Heart Transplanted Patients : Comparison With Multi-detectors Scanner
Lead Sponsor:
University Hospital, Caen
Conditions:
Heart Disease
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Heart transplantation is the ultimate therapeutic option in patients with end-stage heart failure. Since advances in the treatment of acute rejection has increased early transplant survival, cardiac a...
Detailed Description
Aim of the study. The aim of the study is to compare the quantitative (using 15O-H2O PET) and semi-quantitative (using perfusion CMR) assessment of coronary reserve to the presence of coronary artery ...
Eligibility Criteria
Inclusion
- Patient with heart transplantation \> 3 years
- Candidate to a routine coronary angiography
- Age \> 18 years old
- signed informed consent
Exclusion
- Pregnancy or breast feeding women
- Recent acute coronary syndrome (\<4weeks)
- High Blood Pressure ((SBP \>=180 mmHg or DBP \>=110 mmHg)
- Significant ventricular or supraventricular arrythmia
- Atrioventricular 2nd or 3rd degree blocks, long QT syndrome
- Standard contraindications to MRI including pacemaker/defibrillator, metallic clips on brain aneurysms, metal fragment in the eye etc...
- Congestive heart failure
- Hemodynamic instability
- Intolerance or contraindication to adenosine (history of asthma or bronchoplastic disease).
- Severe and known pulmonary artery hypertension
- Severe hypotension \< 90 mmHg
- Contraindication to contrast iodinated media (allergy, patients with chronic renal failure with creatinine clearance \< 50 ml/min, multiple myeloma, hyperthyroidism,...)
Key Trial Info
Start Date :
November 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2014
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT01231815
Start Date
November 1 2010
End Date
December 1 2014
Last Update
April 9 2014
Active Locations (2)
Enter a location and click search to find clinical trials sorted by distance.
1
CHU de Caen - GIP Cyceron
Caen, France, 14000
2
CHU de Rouen
Rouen, France, 76000