Status:
COMPLETED
Effect of N-acetylcysteine (NAC) on Hydrogen Sulfide (H2S) in Chronic Kidney Disease (CKD)
Lead Sponsor:
A.C. Abrahams
Conditions:
Chronic Kidney Disease
Chronic Kidney Failure
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
Cardiovascular morbidity and mortality is high in CKD patients. Nitric oxide (NO) deficiency plays a crucial role in progression of CKD. This leads to endothelial dysfunction, hypertension, and inflam...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Healthy volunteers:
- Adult (\> 18 years and older)
- Healthy, as assessed by medical history, blood pressure, plasma creatinine, and urine dipstick
- No medication use
- CKD patient:
- Adult (\> 18 years and older)
- CKD stage 3-4 (GFR 15-60 ml/min)
- Hemodialysis patient:
- Adult (\> 18 years and older)
- Hemodialysis patient
- Peritoneal dialysis patient:
- Adult (\> 18 years and older)
- Peritoneal dialysis patient
- Exclusion criteria:
- Unable to give informed consent
- Hypersensitivity to N-acetylcysteine
- Pregnancy
Exclusion
Key Trial Info
Start Date :
July 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2011
Estimated Enrollment :
28 Patients enrolled
Trial Details
Trial ID
NCT01232257
Start Date
July 1 2011
End Date
December 1 2011
Last Update
October 26 2012
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
UMC Utrecht
Utrecht, Netherlands, 3584 CX