Status:
WITHDRAWN
Study to Evaluate Esmolol (Brevibloc) to Manage Cardiac Function in Patients With Subarachnoid Hemorrhage
Lead Sponsor:
University of Michigan
Conditions:
Subarachnoid Hemorrhage
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The purpose of this study is to evaluate the clinical effect of esmolol treatment on cardiac function and electrophysiology; to assess the effects of esmolol treatment on serum adrenergic and cardiac ...
Detailed Description
Subarachnoid hemorrhage (SAH) remains one of the most devastating forms of stroke. Over 25% of all stroke related potential years of life lost are from SAH. Outcomes are adversely affected by secondar...
Eligibility Criteria
Inclusion
- Subarachnoid hemorrhage presumed to be the result of ruptured aneurysm
- Age 18 years old or greater
- Able to enroll within 24 hours of onset of symptoms
- Systolic blood pressure over 140 mm Hg OR administration of antihypertensives after presentation
Exclusion
- Withdrawal of life support imminent (within six hours)
- Known heart failure or cardiomyopathy AND ejection fraction 35% or below
- Prisoner or pregnant female
- Ongoing vasopressor administration to maintain SBP, or clinical suspicion of left ventricular failure
- Clinically important arrhythmias (history of cardiac arrest or ventricular arrhythmias), conduction abnormalities (Mobitz Type 2, 3rd degree AV block, or symptomatic Mobitz 1 without pacemaker), clinical cardiogenic shock, or overt clinical heart failure
- Active bronchospastic disease (ongoing bronchospasm after SAH presentation or current treatment with oral corticosteroids for asthma or obstructive lung disease)
- End stage renal disease
Key Trial Info
Start Date :
July 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2016
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT01232400
Start Date
July 1 2014
End Date
August 1 2016
Last Update
January 8 2015
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University of Michigan Health System
Ann Arbor, Michigan, United States, 48109