Status:
COMPLETED
Analysis of Neutrophil Response in Chronic Periodontitis
Lead Sponsor:
Birmingham Community Healthcare NHS
Collaborating Sponsors:
University of Birmingham
Conditions:
Chronic Periodontitis
Eligibility:
All Genders
18+ years
Brief Summary
Recent scientific evidence suggests that the main defence cell of the body (neutrophil) behaves in a different manner in patients with gum disease; namely how they interact with bacteria and their rol...
Eligibility Criteria
Inclusion
- Be aged 18 or over
- Have a minimum of 20 teeth
- Have chronic periodontitis or otherwise healthy volunteers (controls)
- Be capable of giving informed consent themselves and are able and willing to participate in the study
Exclusion
- Patients with aggressive disease
- Mouthwash use
- Special dietary needs (e.g. coeliac)
- Patients with physical or mental disability
- Pregnant women or those breastfeeding
- Patients whose medical history may place them at risk of complications from periodontal therapy (e.g. warfarinised volunteers)
- Patients taking long term anti-microbial or anti-inflammatory drugs
- Patients unable or unwilling to provide informed consent
- Taking dietary supplements (e.g. multivitamins, antioxidants, fish oils)
- Shows unwillingness, inability or lack of motivation to carry out the study procedures, or cannot conform to the protocol
- A course of antibiotic or anti-inflammatory therapy currently or in the previous 3 months
- Current orthodontic treatment (e.g. wearing braces or orthodontic devices)
- Currently participating in another dental trial
- Diabetics
- Smokers or have smoked up to within 5 years
- Those patients who disclose previous or current recreational drug use
Key Trial Info
Start Date :
September 1 2011
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
July 1 2015
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT01233765
Start Date
September 1 2011
End Date
July 1 2015
Last Update
February 14 2017
Active Locations (1)
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1
University of Birmingham School of Dentistry
Birmingham, West Midlands, United Kingdom, B4 6NN