Status:
COMPLETED
Conjugated Linoleic Acid Supplementation Study
Lead Sponsor:
University of Aberdeen
Conditions:
Cardiovascular Disease
Eligibility:
All Genders
30-74 years
Phase:
NA
Brief Summary
Cardiovascular disease is a major cause of mortality worldwide resulting in one out of three global deaths. One of the main characteristics of cardiovascular disease is impaired blood flow and increas...
Detailed Description
Despite being trans fatty acids, dietary conjugated linoleic acids( CLA) have been associated with decreased atherogenesis, beneficial effects on insulin sensitivity , glucose and lipid profile and bo...
Eligibility Criteria
Inclusion
- • Healthy men and women aged 35-74 years
- blood pressure below 160/90 mmHg;
- fasting plasma glucose \< 7 mmol/L;
- total cholesterol \< 8 mmol/L,with cholesterol/HDL ratio \< 6 and/or ASSIGN score \< 20%)
- platelet count \> 170x109/L
- haematocrit above 40 % for males and above 35 % for females
- haemoglobin above 130 g/L for males and above 115 g/L for females
- having a 10-20% risk for developing cardiovascular disease within the next 10 years based on the ASSIGN calculation (http://cvrisk.mvm.ed.ac.uk/index.htm) including the following factors: age, gender, number of cigarettes smoked per day, Scottish Index of Multiple Deprivation (SIMD)/postcode, systolic blood pressure, levels of total and HDL cholesterol and family history of cardiovascular disease or having at least one additional risk factor such as being over 50 years old, BMI above 25 kg/m2, elevated triglyceride levels (\> 1.7 mmol/L) or elevated glucose levels (\> 5.6 mmol/L);
Exclusion
- Exclusion criteria Subjects are excluded if
- They are regularly taking aspirin or aspirin-containing drugs, or other anti-inflammatory drugs;
- They are taking drugs or herbal medicines known to alter platelet function or the haemostatic system in general;
- They are diagnosed with diabetes, hypertension, renal, hepatic, haematological disease or coronary heart disease;
- They are undertaking more than 6 hours vigorous exercise per week
- They are pregnant (or planning to become pregnant) or lactating;
- They have given a pint of blood for transfusion purposes within the last month;
- They have unsuitable veins for blood sampling;
- They are inability to understand the participant information sheet or inability to speak, read and understand the English language.
Key Trial Info
Start Date :
November 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2012
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT01234636
Start Date
November 1 2010
End Date
November 1 2012
Last Update
November 13 2015
Active Locations (1)
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1
Rowett Institute of Nutrition and Health
Aberdeen, Scotland, United Kingdom, AB21 9SB