Status:
COMPLETED
Fish Oil Supplementation in Late-life Depression
Lead Sponsor:
Taipei City Psychiatric Center, Taiwan
Collaborating Sponsors:
National Science and Technology Council, Taiwan
Conditions:
Late-Life Depression
Eligibility:
All Genders
60+ years
Phase:
NA
Brief Summary
To investigate whether fish oil supplementation, compared to placebo (olive oil), could have better effects on depression course and cognitive function in older people with major depression.
Detailed Description
Patients with late-life depression were reported cognitive impairment, especially in information-processing speed, working memory, attention and episodic memory, even after depressive symptoms subside...
Eligibility Criteria
Inclusion
- An age range of 60 years old or over;
- A previous diagnosis of major depressive disorder according to the Chinese version of Structured Clinical Interview for DSM IV-TR Axis-I Disorder;
- Depressive symptoms were stable for at least three consecutive weeks and the 17-item Hamilton Depression Rating Scale score less or equal to 10.
- Capacity to provide informed consent.
Exclusion
- People with severe or acute medical illness ( such as metastatic cancer, brain tumor, decompensated cardiac, hepatic, or renal failure, or myocardial infarction or stroke) within the 3 months preceding the study.
- Those who had neurological disorders involving central nervous system, such as delirium, Parkinson's disease, aphasia or multiple sclerosis)
- Prominent cognitive impairment, defined as the Chinese version of Mini-Mental State examination score less than 17.
- People with alcoholism, defined by a score of 8 or higher in male and of 6 or higher in female on the Chinese version of the Alcohol Use Disorders Identification Test (AUDIT) questionnaire.
Key Trial Info
Start Date :
May 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2010
Estimated Enrollment :
89 Patients enrolled
Trial Details
Trial ID
NCT01235533
Start Date
May 1 2007
End Date
September 1 2010
Last Update
November 5 2010
Active Locations (2)
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1
Chih-Chiang Chiu
Taipei, Taiwan, 110
2
Department of Psychiatry, Cathay General Hospital
Taipei, Taiwan