Status:
COMPLETED
The Effect of Avocado on Cardiovascular Disease (CVD) Risk Factors
Lead Sponsor:
Penn State University
Collaborating Sponsors:
Hass Avocado Board
Conditions:
Cardiovascular Disease
Hyperlipidemia
Eligibility:
All Genders
21-70 years
Phase:
NA
Brief Summary
The investigators propose to evaluate the effects of avocado consumption (by incorporating 1 unit of fruit per day into a healthy diet) on multiple cardiovascular disease (CVD) risk factors. The inves...
Detailed Description
A randomized, 3-period cross-over, controlled feeding study was designed to compare the effects of a moderate fat blood cholesterol-lowering diet that provides one avocado per day (total fat = 34% tot...
Eligibility Criteria
Inclusion
- healthy non-smoking
- overweight (BMI 25-35 kg/m2) men and women
- LDL-C between the25-90th percentile from NHANES: 105-194mg/dL for males; 98-190mg/dL for females)
Exclusion
- BP \>140/90 mmHg;
- A history of myocardial infarction, stroke, diabetes mellitus, liver disease, kidney disease, and thyroid disease (unless controlled on medication);
- Lactation, pregnancy, or desire to become pregnant during the study;
- Cholesterol-lowering medication use;
- Intake of putative cholesterol-lowering supplements (psyllium, fish oil capsules, soy lecithin, niacin, fiber, flax, and phytoestrogens, stanol/sterol supplemented foods);
- Vegetarianism;
- Nut allergies (Other food allergies were reviewed on a case-by-case basis);
- Refusal to discontinue nutritional supplements, herbs or vitamins
Key Trial Info
Start Date :
November 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2013
Estimated Enrollment :
54 Patients enrolled
Trial Details
Trial ID
NCT01235832
Start Date
November 1 2010
End Date
February 1 2013
Last Update
August 21 2023
Active Locations (1)
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1
Penn State University
University Park, Pennsylvania, United States, 16802