Status:
COMPLETED
Weaning And Variability Evaluation
Lead Sponsor:
Ottawa Hospital Research Institute
Collaborating Sponsors:
Canadian Institutes of Health Research (CIHR)
Conditions:
Mechanically Ventilated Patients
Extubation
Eligibility:
All Genders
18+ years
Brief Summary
Knowing when to liberate patients from mechanical ventilation (i.e. removal of breathing or endotracheal tube or extubation) is critically important, as both prolonged ventilation and failed extubatio...
Eligibility Criteria
Inclusion
- Invasive mechanical ventilation for \>48 hours,
- patient is ready for SBTs for assessment for extubation,
- has a normal sinus rhythm at time of SBT (no pacemaker),
- is tolerating pressure support ventilation ≤14 cm H2O (SpO2 ≥ 90% with FiO2 ≤ 40% and PEEP ≤ 10 cm H2O),
- hemodynamically stable (low or no vasopressors), stable neurological status (no deterioration in GCS during prior 24 hours \& ICP \< 20),
- intact airway reflexes (cough \& gag).
Exclusion
- Order not to re-intubate,
- anticipated withdrawal of life support,
- known or suspected severe weakness (myopathy, neuropathy or quadriplegia),
- tracheostomy,
- and prior extubation during ICU stay.
Key Trial Info
Start Date :
November 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 1 2012
Estimated Enrollment :
660 Patients enrolled
Trial Details
Trial ID
NCT01237886
Start Date
November 1 2009
End Date
November 1 2012
Last Update
July 7 2017
Active Locations (14)
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1
The University of Michigan Medical Center
Ann Arbor, Michigan, United States, 48109-5048
2
Billings Clinic
Billings, Montana, United States, 59107
3
Dartmouth Hitchcock Memorial Hospital
Lebanon, New Hampshire, United States, 03756
4
Columbia University
New York, New York, United States, 10032