Status:

COMPLETED

The Genetics of Severe Asthma in Children

Lead Sponsor:

Connecticut Children's Medical Center

Collaborating Sponsors:

UConn Health

Conditions:

Asthma

Eligibility:

All Genders

4-18 years

Brief Summary

Near fatal asthma exacerbations are one of the most common causes of critical illness in children, accounting for approximately ten thousand intensive care unit (ICU) admissions per year in the United...

Detailed Description

Our primary outcome measure is the development of a near fatal asthma exacerbation. Secondary outcome measures will include the duration of continuously nebulized ADRβ2 agonist therapy and the duratio...

Eligibility Criteria

Inclusion

  • Inclusion Criteria, inpatient asthmatics:
  • Admission to study institution with a primary admission diagnosis of asthma exacerbation
  • Age between 4 and 18 years
  • Exclusion Criteria, inpatient asthmatics:
  • \- Pre-existing chronic disease (other than asthma), including: i. bronchopulmonary dysplasia ii. bronchomalacia iii. tracheomalacia iv. laryngomalacia v. vocal cord dysfunction vi. chronic restrictive lung disease vii. recurrent aspiration pneumonia viii. impaired mucous clearance ix. congenital heart disease x. pulmonary hypertension
  • Inclusion Criteria, outpatient asthmatics:
  • Diagnosis of asthma
  • Age between 4 and 18 years
  • Exclusion Criteria, outpatient asthmatics:
  • Previous admission to the hospital for a near fatal asthma exacerbation
  • Pre-existing chronic disease (other than asthma) including i. bronchopulmonary dysplasia ii. bronchomalacia iii. tracheomalacia iv. laryngomalacia v. vocal cord dysfunction vi. chronic restrictive lung disease vii. recurrent aspiration pneumonia viii. impaired mucous clearance ix. congenital heart disease x. pulmonary hypertension
  • Inclusion Criteria, healthy controls:
  • \- Age between 4 and 18 years
  • Exclusion Criteria, healthy controls:
  • \- Pre-existing chronic disease including: i. asthma ii. bronchopulmonary dysplasia iii. bronchomalacia iv. tracheomalacia v. laryngomalacia vi. vocal cord dysfunction vii. chronic restrictive lung disease viii. recurrent aspiration pneumonia ix. impaired mucous clearance x. congenital heart disease xi. pulmonary hypertension

Exclusion

    Key Trial Info

    Start Date :

    October 1 2009

    Trial Type :

    OBSERVATIONAL

    Allocation :

    ACTUAL

    End Date :

    April 1 2018

    Estimated Enrollment :

    193 Patients enrolled

    Trial Details

    Trial ID

    NCT01238432

    Start Date

    October 1 2009

    End Date

    April 1 2018

    Last Update

    November 30 2023

    Active Locations (1)

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    Connecticut Children's Medical Center

    Hartford, Connecticut, United States, 06103