Status:
COMPLETED
Identification and Characterization of the Methylation Abnormalities on Whole Genome Among Infertile Men
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Conditions:
Oligospermia
Eligibility:
MALE
18-45 years
Brief Summary
This study will analyse the sperm global methylation status of 62 infertile men before assisted reproductive techniques. Some of these patients (20%) present hypomethylation of H19 locus. A global met...
Detailed Description
An increase of the abnormalities of the imprint was brought back at the child's stemming from assisted reproductive techniques. Now abnormalities of methylation could be implied in defects of spermato...
Eligibility Criteria
Inclusion
- Men from 18 to 45 years old, presenting an idiopathic oligozoospermia lower than 10 million sperm cells / ml and include in a program of medically assisted conception
- Patients with social security
- Patients having signed the informed consent
Exclusion
- Infertility with a neoplastic origin: patients subjected to a treatment potentially sterilizing (chemotherapy or radiotherapy).
- Infertility with an infectious origin
- Infertility with a traumatic origin
- Infertility bound to a chromosomal abnormality or a microdeletion of Y
- Histories of cryptorchidism, of varicocele
Key Trial Info
Start Date :
June 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2012
Estimated Enrollment :
49 Patients enrolled
Trial Details
Trial ID
NCT01239186
Start Date
June 1 2009
End Date
December 1 2012
Last Update
August 7 2013
Active Locations (1)
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1
Department of Biology of reproduction (TENON Hospital)
Paris, Île-de-France Region, France, 75020