Status:
COMPLETED
Biomarkers and Knee Osteoarthritis
Lead Sponsor:
University of British Columbia
Collaborating Sponsors:
Canadian Arthritis Network
Conditions:
Knee Osteoarthritis
Eligibility:
All Genders
50-85 years
Phase:
NA
Brief Summary
High joint load during walking has been linked to cartilage degradation. Biomarkers, found in the blood and urine, are protein fragments released after cartilage degradation characteristic of OA. They...
Detailed Description
Participants will be tested twice (baseline and 11 weeks later) where they will undergo gait and strength analyses by the same blinded assessor, complete self-report questionnaires, and have blood and...
Eligibility Criteria
Inclusion
- age greater than 50 years (to meet the American College of Rheumatology clinical definition of OA)
- radiographically confirmed knee OA in the medial compartment of the tibiofemoral joint
- knee pain during walking greater than 3/10 (based on an 11-point scale; 0 = "no pain", 10 = "maximal pain") on most days of the previous month
- predominance of pain/tenderness over the medial (inside) region of the knee
Exclusion
- articular cartilage degradation in the lateral tibiofemoral compartment greater than the medial (medial compartment OA is more common than lateral and the KAM is a validated measure of medial compartment loading only)
- currently in a structured exercise program
- medical condition precluding exercise
- inflammatory arthritic condition
- history of knee replacement surgery
- recent use of corticosteroids (oral or via injection)
- unable to attend exercise training sessions at UBC
- pain originating predominantly from the patellofemoral joint
- inability to ambulate without a gait aid
- non-English speaking (questionnaires are in English and must be completed by the study participant only)
- recent (within 6 months) arthroscopic knee surgery
- significant hip or back pain (limits the ability to perform the testing and exercises)
Key Trial Info
Start Date :
October 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2011
Estimated Enrollment :
17 Patients enrolled
Trial Details
Trial ID
NCT01241812
Start Date
October 1 2010
End Date
September 1 2011
Last Update
October 12 2017
Active Locations (1)
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1
University of British Columbia
Vancouver, British Columbia, Canada