Status:
COMPLETED
Efficacy and Security of Intrapleurally Alteplase vs Urokinase for the Treatment of Complicated Parapneumonic Effusion and Empyema
Lead Sponsor:
Hospital Universitari Vall d'Hebron Research Institute
Conditions:
Empyema, Pleural
Pleural Effusion
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
1. Objectives: * Main objective: To evaluate the efficacy and safety of intrapleural alteplase vs urokinase in patients with complex complicated parapneumonic pleural effusion and empyema. * To...
Eligibility Criteria
Inclusion
- Empyema and Complex Complicated Parapneumonic Pleural Effusion
Exclusion
- Pregnancy or breastfeeding
- Critically illness
- Systemic anticoagulant treatment
- Coagulation Disorder
- Bronchopleural fistula
- Active bleeding
- Recent punction of noncompressive artery
- Stroke in the last 6 months
- Major intervention o major traumatism in the last 6 weeks
- Hypersensibility to urokinase or alteplase
- Severe Liver or kidney failure
- Inclusion in another interventional study in the last month
Key Trial Info
Start Date :
December 1 2003
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2010
Estimated Enrollment :
204 Patients enrolled
Trial Details
Trial ID
NCT01246453
Start Date
December 1 2003
End Date
December 1 2010
Last Update
July 18 2011
Active Locations (2)
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1
Hospital Vall d'Hebron
Barcelona, Catalonia, Spain, 5
2
Hospital Arnau de Vilanova
Lleida, Catalonia, Spain