Status:

COMPLETED

Sunitinib and Atrial Trabeculae Contractility

Lead Sponsor:

Radboud University Medical Center

Conditions:

Cardiotoxicity

Ischemia

Eligibility:

All Genders

18+ years

Brief Summary

Rationale: Recently, sunitinib (a tyrosine kinase inhibitor that is used for treatment of metastatic renal carcinoma and gastrointestinal stroma tumors) has been associated with development of heart ...

Detailed Description

Study population: 44 (+22) patients undergoing CABG cardiac surgery with extracorporal circulation Intervention (if applicable): none (pharmacological interventions will only be performed ex-vivo in i...

Eligibility Criteria

Inclusion

  • Cardiac surgery with extracorporal circulation

Exclusion

  • Use of oral antiarrhythmics
  • theophylline use
  • Use of sulfonylureas
  • Atrial arrythmias
  • Right ventricular failure

Key Trial Info

Start Date :

November 1 2010

Trial Type :

OBSERVATIONAL

Allocation :

ACTUAL

End Date :

April 1 2014

Estimated Enrollment :

20 Patients enrolled

Trial Details

Trial ID

NCT01246778

Start Date

November 1 2010

End Date

April 1 2014

Last Update

May 1 2014

Active Locations (1)

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Radboud University Nijmegen Medical Centre

Nijmegen, Netherlands, 6500HB