Status:
UNKNOWN
MIBG Scintigraphy and Strain Echocardiography in the Detection of Subclinical Cardiovascular Effects One Year After (Neo)Adjuvant Breast Cancer Treatment With Docetaxel, Doxorubicin and Cyclophosphamide (TAC): a Pilot Study
Lead Sponsor:
Radboud University Medical Center
Conditions:
Breast Cancer
Eligibility:
FEMALE
18+ years
Brief Summary
Many patients with breastcancer in the past, were treated with TAC. These last years, there is more and more focus on the effects of chemotherapy, particularly in children treated with this. One of th...
Detailed Description
Given the lack of data on the incidence of subclinical cardiotoxicity after treatment with TAC we want to assess whether subclinical cardiovascular damage is present in adult patients with breast canc...
Eligibility Criteria
Inclusion
- Female patients with breast cancer, ≥ 18 years old at the time of breast cancer diagnosis
- (Neo)adjuvant treatment with docetaxel, doxorubicin and cyclophosphamide (TAC) completed one year before inclusion
Exclusion
- Evidence of breast cancer recurrence or metastatic disease
- Evidence of heart disease at the time of breast cancer diagnosis
- Evidence of renal failure at the time of cardiac evaluation
- Pregnant or lactating
- Participation in a research protocol with ionizing radiation within one year before inclusion.
- Evidence of diabetes mellitus or Parkinson's disease
- Evidence of an MIBG-accumulating tumor (pheochromocytoma, paraganglioma, chemodectoma, ganglioneuroma, neuroblastoma, carcinoid, medullary thyroid cancer, neurofibromatosis, retinoblastoma, esthesioneuroma, schwannoma, merkelcel-tumor, pancreatic islet cell tumors, small cell lung carcinoma, melanoma
Key Trial Info
Start Date :
November 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT01246856
Start Date
November 1 2010
Last Update
September 12 2011
Active Locations (1)
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1
University Medical Centre Nijmegen
Nijmegen, Gelderland, Netherlands, 6500 HB