Status:
UNKNOWN
Effect of Fluticasone Proprionate 0.05% on Narrow Band UV-B in Active Vitiligo
Lead Sponsor:
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Conditions:
Patients With Active Non-segmental Vitiligo.
Evaluation of the Efficacy of UVB and Fluticason Proprionate 0.05%
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
Rationale: Vitiligo vulgaris is a common acquired pigment disorder, which is characterised by the development of depigmented macules. It develops probably due to immunedestruction of melanocytes. Most...
Eligibility Criteria
Inclusion
- non-segmental vitiligo
- Eligible for NB-UVB therapy
- Subjects attending the outpatient department of the SNIP
- patients \> 18 years
- Skin type II-V
- patients with active vitiligo: progression of older lesions or development of new lesion during the last 6 months
- Subject is willing and able to give written informed consent
Exclusion
- Personal or a family history of skin cancer ( non-melanoma skincancer: first degree family members, melanoma: any family members)
- Personal history of photosensitivity and/or phototoxicity disorders
- pregnancy
- Taking medication known to cause photosensitivity, phototoxicity, immune suppression and chronic or very frequent use of any medication that can influence the UVB response (e.g. tetracycline, retinoids, sulfonamids, psoralens)
- Other skin diseases that would impair the evaluation of repigmentation
- not able to have 2 times weekly NB-UVB phototherapy
- With local immunosuppressive treatment or 6 weeks prior to enrolment. For these patients a washout period of 6 weeks will be required.
- Contact-allergy for any of the parts in fluticasone proprionate
Key Trial Info
Start Date :
September 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT01246921
Start Date
September 1 2009
Last Update
November 24 2010
Active Locations (1)
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1
Netherlands Institute for Pigments Disorders
Amsterdam, Netherlands, 1105AZ