Status:
COMPLETED
Comparison of Tranexamic to Epsilon Aminocaproic Acid: a Prospective Analysis of Blood Conservation in Cardiac Surgery
Lead Sponsor:
Loma Linda University
Conditions:
Cardiopulmonary Bypass
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
We designed a prospective double-blinded randomized trial in an attempt to detect a difference between tranexamic acid (TXA) and epsilon aminocaproic acid (EACA) in reducing transfusion in patients un...
Detailed Description
Background: This study compares the efficacy of tranexamic acid (TXA) to epsilon aminocaproic acid (EACA) in reducing blood loss in patients undergoing cardiac surgery. Methods: This was a double-blin...
Eligibility Criteria
Inclusion
- Is the subject 18 years of age or older?
- Is the subject scheduled for primary cardiac surgery utilizing cardiopulmonary bypass(CPB)?
- Is the subject more than 30 kg ( 66 lbs)?
- Does subject understand English?
Exclusion
- Does the subject have existing coagulation defects (INR \> 1.5, platelets \< 100 ?
- Does the subject have renal failure (defined as BUN/Cr ratio 20:1 ?
- Does the subject have severe liver disease (AST \& ALT\> 3x normal) ?
- Is the subject having emergency cardiac surgery, complex aortic surgery, combination valve/CABG surgeries, or redo cardiac surgery?
- Is the subject having any procedure where CPB is not anticipated?
- Is the patient weight greater than 150 kg?
Key Trial Info
Start Date :
March 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2015
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT01248104
Start Date
March 1 2010
End Date
February 1 2015
Last Update
October 19 2020
Active Locations (1)
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1
Loma Linda University Medical Center
Loma Linda, California, United States, 92354