Status:
COMPLETED
Stress-induced Vascular Dysfunction: Evaluation of Endothelial Function in a Cohort of Patients With Takotsubo Syndrome
Lead Sponsor:
University of Zurich
Conditions:
Takotsubo Syndrome
Eligibility:
All Genders
18-80 years
Brief Summary
The aim of this prospective single-center study is to evaluate endothelial function, arterial compliance, sympathetic nervous activity at rest and after mental and physical stress, carotid atheroscler...
Detailed Description
The aim of this prospective single-center study is to evaluate endothelial function, arterial compliance, sympathetic nervous activity at rest and after mental and physical stress, carotid atheroscler...
Eligibility Criteria
Inclusion
- Inclusion criteria: We plan to include male or female subjects, age 18-80 with a diagnosis of Takotsubo Syndrome (according to standard clinical criteria\[Strony, J., et al., Analysis of shear stress and hemodynamic factors in a model of coronary artery stenosis and thrombosis. Am J Physiol, 1993. 265(5 Pt 2): p. H1787-96.\]) in the last 10 years.
- Moreover, patients matched to the Takotsubo patients for age and cardiovascular risk factors will be included in the control group.
- All patients will signed an written informed consent
- Exclusion criteria:
- Long acting nitrates, or PDE-5-Hemmer
- Alcohol or drug abuse,
- Malignancy (unless healed or remission \> 5 years)
- Disease with systemic inflammation (e.g. rheumatoid arthritis, M. Crohn)
- Pulmonary Hypertension
- Participation in another study within the last month
Exclusion
Key Trial Info
Start Date :
November 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 1 2012
Estimated Enrollment :
44 Patients enrolled
Trial Details
Trial ID
NCT01249599
Start Date
November 1 2010
End Date
October 1 2012
Last Update
December 11 2012
Active Locations (1)
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1
University Hospital Zurich, Division of Cardiology
Zurich, Canton of Zurich, Switzerland, 8091