Status:
COMPLETED
Acute Effects of Cinacalcet on Arterial Stiffness and Ventricular Function in Hemodialysis Patients
Lead Sponsor:
Laval University
Collaborating Sponsors:
Amgen
Conditions:
Chronic Kidney Disease
Eligibility:
All Genders
18-80 years
Phase:
PHASE4
Brief Summary
The primary objective is to determine whether reduction of serum calcium concentration by cinacalcet leads to reduction of mean blood pressure adjusted c-fPWV. The secondary objectives are to study th...
Eligibility Criteria
Inclusion
- chronic (\> 3 months) hemodialysis population of \> 18 years old
- PTH \> 300 ng/L
- corrected Ca \> 2.10 mmol/L
- stable hypertensive drugs (\> 1 month)
- stable doses of phosphate binders and dialysis calcium concentration
- palpable femoral pulse
- systolic BP of 90-180 mmHg
- expected survival of \> 6 months
Exclusion
- hemodialysis \> 3 years
- acute infection
- history of myocardial infarction or stroke within the past 3 months
- inability to consent
- intolerance to cinacalcet
- inadequate birth control
Key Trial Info
Start Date :
May 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2014
Estimated Enrollment :
23 Patients enrolled
Trial Details
Trial ID
NCT01250405
Start Date
May 1 2012
End Date
April 1 2014
Last Update
April 7 2014
Active Locations (1)
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1
Karine Marquis
Québec, Quebec, Canada, G1R2J6