Status:
COMPLETED
Effects of Alpha Blockers on Prostate-specific Antigen (PSA) Change in Men With Lower Urinary Tract Symptoms (LUTS)
Lead Sponsor:
Seoul National University Hospital
Conditions:
Benign Prostatic Hyperplasia
Prostate Cancer
Eligibility:
MALE
40-80 years
Brief Summary
The correlation between the change of serum prostate-specific antigen (PSA) or PSA velocity (PSAV) and severity of lower urinary tract symptoms (LUTS) has been poorly understood. Previous studies usua...
Detailed Description
Since successful treatment with alpha-1 adrenergic antagonists, or AB was reported first in 1975, the therapeutic efficacy has been widely accepted and now AB medication is considered the first-line c...
Eligibility Criteria
Inclusion
- more than two consecutive PSA measurements before the biopsy and the medication periods of AB more than 3 months in all patients
Exclusion
- any prostate surgery during the study period, any prostate disease with evidence of prostatic inflammation, any urologic surgery before PSA measurement, and medication history of anticholinergics or 5-alpha reductase inhibitors
Key Trial Info
Start Date :
January 1 2001
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2009
Estimated Enrollment :
174 Patients enrolled
Trial Details
Trial ID
NCT01250483
Start Date
January 1 2001
End Date
December 1 2009
Last Update
November 30 2010
Active Locations (1)
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1
Seoul National University Hospital
Seoul, Seoul, South Korea, 110-744