Status:
UNKNOWN
Genomic Study of Congenital Malformation
Lead Sponsor:
China Medical University Hospital
Collaborating Sponsors:
Academia Sinica, Taiwan
Conditions:
Genomic Aberrations in Patients Diagnosed as Congenital Malformation With Unknown Etiology
Eligibility:
All Genders
Brief Summary
Genomic aberrations in patients diagnosed as congenital malformation with unknown etiology will be identified using high-density oligonucleotide array.
Detailed Description
The Affymetrix GeneChip® Human Mapping SNP 6.0 array, includes more than 900,000 SNP probes plus more than 900,000 CNV probes in a single chip, can provide high density makers information for the huma...
Eligibility Criteria
Inclusion
- Subject is diagnosed as congenital malformation/syndromes.
- Participants can be any ages, and both males and females are eligible.
- Subjects agree and are capable of giving informed consent. If participants are under 18 years old or incapable of giving consent, an informed consent must be approved by their legal guardians.
- Availability and willingness of the proband and first-degree biological family (parents, full sibling, or adult-age offspring) who also meets the same congenital malformation syndrome.
- Availability and willingness of the proband's biological parents whatever with or without the same congenital malformation syndrome.
Exclusion
- Subject or legal guardian is unable to understand or give informed consent.
- The molecular cause for congenital malformation/syndromes of subjects or their affected first-degree biological family (parents, full sibling, or adult-age offspring) can be revealed by karyotype assay or FISH.
Key Trial Info
Start Date :
June 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
900 Patients enrolled
Trial Details
Trial ID
NCT01250613
Start Date
June 1 2010
Last Update
December 1 2010
Active Locations (1)
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1
China Medical University Hospital
Taichung, Taiwan, Taiwan, 406