Status:
COMPLETED
Neural, Genetic, and Peripheral Correlates of SSRI Pharmaco-Response
Lead Sponsor:
Medical University of Vienna
Conditions:
Depression
Eligibility:
All Genders
18-45 years
Phase:
PHASE4
Brief Summary
The aim of this pharmaco-MRI study is to investigate neural correlates of variable antidepressant treatment response driven by genetic variation in multiple genes involved in depression. Thirty Major...
Detailed Description
The aim of this pharmaco-MRI study is to investigate neural correlates of variable antidepressant treatment response driven by genetic variation in multiple genes involved in depression. Thirty Major...
Eligibility Criteria
Inclusion
- Male or female
- Age 18 -45 years
- Right-handedness
- DSM-IV diagnosis of a major depressive episode (SCID)
- a MADRS score ≥20 and ≤ 30
- ability to be managed as outpatients
- ability to fulfill the criteria to undergo an MRI scan
- Caucasian subjects of European ancestry
Exclusion
- previous or concurrent major medical or neurological illness
- clinically significant abnormal values in routine laboratory screening or general physical examination
- DSM-IV diagnosis of substance dependence within the past year, except for caffeine or nicotine or current substance abuse
- DSM-IV diagnosis of schizophrenia, schizoaffective disorder, bipolar disorder, or an anxiety disorder as a primary diagnosis
- the use of any psychotropic drug within the last two months unresponsiveness of a former major depressive episode to an adequate antidepressive drug dosing of at least 6 weeks duration or any kind of therapy resistance
- a history of severe drug allergy or hypersensitivity or known hypersensitivity to escitalopram
- being acutely suicidal either indicated by a score ≥ 5 on item 10 (suicidal thoughts) on the MADRS or a score ≥ 4 on the HAM-D 21 (suicidal thoughts) or according to the investigator´s opinion
- failures to comply with the study protocol or to follow the instructions of the investigating team
- current pregnancy or breast feeding
- metallic implants or other contraindications to MRI
Key Trial Info
Start Date :
August 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2015
Estimated Enrollment :
26 Patients enrolled
Trial Details
Trial ID
NCT01251471
Start Date
August 1 2011
End Date
March 1 2015
Last Update
October 31 2016
Active Locations (1)
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1
Medical University of Vienna, Dept. of Psychiatry and Psychotherapy
Vienna, Vienna, Austria, 1090