Status:
COMPLETED
Bile Acid-induced GLP-secretion. A Study in Cholecystectomized Subjects
Lead Sponsor:
University Hospital, Gentofte, Copenhagen
Conditions:
Diabetes
Eligibility:
All Genders
18-70 years
Brief Summary
PURPOSE The goal of the present project is to unravel the importance of bile acid-induced GLP-1 secretion (via the G protein-coupled receptor TGR5) in human physiology. In the present study the inve...
Eligibility Criteria
Inclusion
- (Healthy)
- Normal fasting plasma glucose
- Normal glucose tolerance
- Normal haemoglobin levels
- Informed content
- (cholecystectomy group)
- Laparoscopic cholecystectomy \<6 months. Indication: Gallstones.
- Normal fasting plasma glucose
- Normal glucose tolerance
- Normal haemoglobin levels
- Informed content
Exclusion
- (both groups)
- Diabetes
- Pre diabetes (impaired glucose tolerance or impaired fasting glucose)
- 1st degree relatives with diabetes
- Obesity (BMI \> 30)
- Inflammatory bowels disease
- Nephropathy
- Liver disease
- Medication which cannot be on hold for 24h
Key Trial Info
Start Date :
October 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 1 2011
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT01251510
Start Date
October 1 2010
End Date
June 1 2011
Last Update
January 23 2013
Active Locations (1)
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1
Gentofte University Hospital
Hellerup, Denmark, 2900