Status:
COMPLETED
Human Intestinal Amino Acid Absorption and the Role of a Local (Renin)-Angiotensin System (RAS)
Lead Sponsor:
University of Zurich
Conditions:
Healthy Participants
Hypertension
Eligibility:
All Genders
18-80 years
Brief Summary
Aim of this trial is to investigate the expression and localisation of different amino acid transporters and their regulatory proteins derived from the regulatory proteins of the local renin angiotens...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Men and women aged 18-80 years
- BMI 18-35 kg/m2
- Group 1: patients taking daily RAS-active drugs, like ACE inhibitors or sartanes (treatment indication outside of this study)
- Group 2: no therapy with RAS-active drugs, like ACE inhibitors or sartanes Gastroduodenoscopy and/or colonoscopy with a treatment indication outside of this study
- Informed consent
- Exclusion criteria:
- Severe pathologic alterations in the gastrointestinal tract (ulcers, tumors, celiac disease; GERD and gastritis are no exclusion criteria)
- Status after operations of the gastrointestinal tract (except uncomplicated appendectomy or inguinal hernia repair)
- Patients with malignant diseases
- Severe acute or chronic diseases which require treatment (e.g. renal replacement therapy)
- Patients with increased bleeding risk (e.g. oral anticoagulation, coagulopathy)
- Drug or alcohol abuse
- Mental disorders which limits the ability to fulfil all study requirements
Exclusion
Key Trial Info
Start Date :
December 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 1 2011
Estimated Enrollment :
48 Patients enrolled
Trial Details
Trial ID
NCT01252368
Start Date
December 1 2009
End Date
May 1 2011
Last Update
November 29 2012
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University Hospital Zurich, Gastroenterology and Hepatology
Zurich, Canton of Zurich, Switzerland, 8091