Status:
UNKNOWN
Serial Retinal Thickness Changes And Scotoma Size Measured With Lucentis Therapy
Lead Sponsor:
The New York Eye & Ear Infirmary
Collaborating Sponsors:
Genentech, Inc.
Conditions:
Age Related Macular Degeneration
Eligibility:
All Genders
51-90 years
Phase:
PHASE3
Brief Summary
The rationale for evaluating LucentisTM (a recombinant humanized anti-human Vascular Endothelial Growth Factor (VEGF) monoclonal antibody (Fab) in patients with neovascular (wet) Age related Macular D...
Eligibility Criteria
Inclusion
- Ability to provide written informed consent and comply with study assessments for the full duration of the study
- Subjects of either gender, Age \> 50 years
- Best corrected visual acuity in the study eye between 20/40 and 20/320.
- Subfoveal choroidal neovascularization, secondary to age related macular degeneration.
- Any subretinal hemorrhage must comprise no more than 50% of total lesion size.
- Clear ocular media and adequate papillary dilation to permit good quality stereoscopic fundus photography
- Men must use barrier contraception or abstinence throughout the study.
- Ability to return for all study visits
Exclusion
- Had ocular surgery within the past 60 days in the study eye.
- Had previous refractive eye surgery (RK, PRK, LASIK, ALK, etc.) within the past 3 months for the study eye.
- Has intraocular pressure ≥ 25 mmHg in the study eye.
- Has posterior uveitis in the study eye.
- Has ongoing infection in the study eye.
- Has retinal or optic nerve disease that could independently affect visual acuity including high axial myopia (\>-8.00 D) and diabetic retinopathy in the study eye.
- Has anterior segment and vitreous abnormalities that would preclude adequate observation of the fundus for photographs and fluorescein angiography in the study eye.
- Has received investigational therapy within 60 days prior to study entry.
- Has been previously enrolled in or previous treatment with MSI-1256F for injection.
- Has received prior approved treatment for subfoveal CNV within 60 days to study entry.
- Has clinically uncontrolled diabetes mellitus.
- Has other condition the investigator considers to be sound reasons for exclusion (e.g., lack of motivation, history of poor compliance, concomitant illnesses, personality disorder, mental condition, drug abuse, use of neuroleptics, physical or social condition predicting difficulty in long-term follow-up).
- Has an allergy to sodium fluorescein dye.
- Currently uses systemic or topical medications known to be toxic to the retina, lens, or optic nerve, such as deferoxamine, chloroquine/hydrochloroquine, tamoxifen, chlorpromazine, phenothiazines, steroids and ethambutol.
- Pregnancy (positive pregnancy test) or lactation
- Premenopausal women not using adequate contraception. The following are considered effective means of contraception: surgical sterilization or use of oral contraceptives, barrier contraception with either a condom or diaphragm in conjunction with spermicidal gel, an IUD, or contraceptive hormone implant or patch.
Key Trial Info
Start Date :
June 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2012
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT01255774
Start Date
June 1 2007
End Date
December 1 2012
Last Update
December 5 2011
Active Locations (1)
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1
New York Eye and Ear Infirmary
New York, New York, United States, 10003