Status:
COMPLETED
Efficacy of Riluzole in Surgical Treatment for Cervical Spondylotic Myelopathy (CSM-Protect)
Lead Sponsor:
AOSpine North America Research Network
Conditions:
Cervical Spondylotic Myelopathy
Eligibility:
All Genders
18-80 years
Phase:
PHASE3
Brief Summary
CSM (Cervical spondylotic myelopathy) is the most common cause of spinal cord injury worldwide. While there is evidence from the recently completed SpineNet prospective study that surgical decompressi...
Eligibility Criteria
Inclusion
- Age between 18 and 80 years
- Diagnosis of symptomatic cervical spondylotic myelopathy defined as a combination of:
- one or more of the following symptoms:
- Numb hands
- Clumsy hands
- Impairment of gait
- Bilateral arm paresthesiae
- l'Hermitte's phenomena
- Weakness And,
- one or more of the following signs:
- Corticospinal distribution motor deficits
- Atrophy of hand intrinsic muscles
- Hyperreflexia
- Positive Hoffman sign
- Upgoing plantar responses
- Lower limb spasticity
- Broad based, unstable gait And,
- MRI evidence of cervical spondylotic myelopathy
- Scheduled for an elective surgery for cervical spondylotic myelopathy
- Preoperative mJOA score ≥8 and ≤14
- Women of child bearing potential must be:
- Postmenopausal defined as amenorrhea for at least 2 years.
- Surgically sterile, (have had a hysterectomy or bilateral oophorectomy, tubal ligation, or otherwise be incapable of pregnancy)
- Abstinent (at the discretion of the investigator)
- Having other congenital or medical condition that prevents subject from becoming pregnant
- If sexually active, be practicing an effective method of birth control such as hormonal prescription oral contraceptives, progesterone implants or injections, intrauterine device (IUD), or male partner with a vasectomy. A double-barrier method such as condoms, diaphragms or cervical caps with spermicidal foam, cream or gel may be used as a birth control method.
- Women of childbearing potential must have a negative serum β-human chorionic gonadotropin (β-hCG) pregnancy test or a negative urine pregnancy test at screening before the first dose of study drug is received.
Exclusion
- Previous surgery for CSM
- Concomitant symptomatic lumbar stenosis
- CSM symptoms due to cervical trauma (at the discretion of the investigator)
- Hypersensitivity to riluzole or any of its components
- Neutropenia measured as absolute neutrophil count (ANC) measured in cells per microliter of blood of \< 1500 at screening visit
- Creatinine level of \> 1.2 milligrams (mg) per deciliter (dl) in males or \> 1.1 milligrams per deciliter in females at screening visit Liver enzymes (ALT or AST) 3x higher than normal values at screening visit.
- Liver enzymes (ALT or AST) 3x higher than normal values at screening visit.
- Subject will be using any of the following medications which are classified as CYP1A2 inhibitors or inducers\*during the course of the drug regimen:
- Inhibitors:
- Ciprofloxacin
- Enoxacin
- Fluvoxamine
- Methoxsalen
- Mexiletine
- Oral contraceptives
- Phenylpropanolamine
- Thiabendazole
- Zileuton
- Inducers:
- Montelukast
- Phenytoin
- \*Note: no washout period required; if these medications are discontinued, subjects are eligible to be enrolled in the trial.
- Systemic infection such as AIDS, HIV, and active hepatitis
- Active malignancy defined as history of invasive malignancy, except if the patient has received treatment and displayed no clinical signs and symptoms for at least five years
- Recent history (less than 3 years) of chemical substance dependency or significant psychosocial disturbance that may impact the outcome or study participation
- Breastfeeding at screening visit and plan to continue during the course of the study drug
- Unlikely to comply with the follow-up evaluation schedule
- Unlikely to comply with investigational drug regime
- Participation in a clinical trial of another investigational drug or device within the past 30 days
- Is a prisoner
- Unable to converse, read or write English at elementary school level
Key Trial Info
Start Date :
March 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2018
Estimated Enrollment :
270 Patients enrolled
Trial Details
Trial ID
NCT01257828
Start Date
March 1 2012
End Date
June 1 2018
Last Update
November 2 2018
Active Locations (21)
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1
Barrow Neurological Institute
Phoenix, Arizona, United States, 85013
2
UC Davis Spine Center
Sacramento, California, United States, 95816
3
University of California - San Francisco
San Francisco, California, United States, 94143
4
Emory University School of Medicine
Atlanta, Georgia, United States, 30329