Status:
COMPLETED
Pioglitazone Attenuates Dysmetabolism in Peritoneal Dialysis (PD) Patients
Lead Sponsor:
Huashan Hospital
Collaborating Sponsors:
Baxter Healthcare Corporation
Conditions:
Peritoneal Dialysis
Pioglitazone
Eligibility:
All Genders
Phase:
NA
Brief Summary
1. Background:Cardiovascular disease (CVD) is the major cause of mortality in peritoneal dialysis (PD) patients, in whom it is partly attributable to a higher prevalence of dysmetabolism. Currently, f...
Detailed Description
Cardiovascular disease (CVD) is the major cause of mortality in chronic kidney disease, including peritoneal dialysis (PD) patients. While survival has not been shown to differ between peritoneal and ...
Eligibility Criteria
Inclusion
- All patients received more than one month regular continuous ambulatory peritoneal dialysis(CAPD) or intermittent peritoneal dialysis(IPD). The causes of chronic renal failure were diabetes and non-diabetes.-
Exclusion
- history of allergy to thiazolidinediones and fenofibrate; history of any sever adverse event for fibrate that can't be tolerated by the patients; patient can not be follow-up regularly; history of myocardial infarction(MI) or coronary artery bypass graft (CABG) surgery within the past 1 month, history of cerebral vascular accident (CVA) or percutaneous transluminal coronary angioplasty(PTCA) within the past 6 months; chronic use of non-steroidal anti-inflammatory drugs(NSAIDs), steroids or immunosuppressives; patient with the acute infection; patient with malignant tumor; have the evidence of severe hepatic injury (ALT/AST\>100u/L).-
Key Trial Info
Start Date :
January 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2008
Estimated Enrollment :
70 Patients enrolled
Trial Details
Trial ID
NCT01258322
Start Date
January 1 2008
End Date
September 1 2008
Last Update
December 10 2010
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