Status:
TERMINATED
The Effect of Transcranial Magnetic Stimulation on Learning With Reward in Healthy Humans
Lead Sponsor:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Normal Physiology
fMRI
Eligibility:
All Genders
18-70 years
Brief Summary
Background: \- Two areas on the surface of the brain, the dorsolateral prefrontal cortex (DLPFC) and motor cortex (MC), play a key role during learning. Researchers are interested in determining the ...
Detailed Description
Objective Theta burst transcranial magnetic stimulation (TBS) produces functional changes in human motor cortex. Continuous inhibitory TBS, (cTBS) over the primary motor cortex (M1) produces a tempor...
Eligibility Criteria
Inclusion
- Participants will be 272 healthy volunteers drawn from the population in the NIH clinical research volunteer program.
- INCLUSION CRITERIA:
- Healthy
- Right-handed
- Ages 18-70 (inclusive)
- Have completed high school or college in an English speaking country.
- All participants must have had a neurological examination by a NINDS physician within the last two years.
- All participants in the fMRI experiments must also have had a clinical MRI within the last year.
- EXCLUSION CRITERIA:
- Individuals with conditions that could pose a risk relating to the safety of the MRI procedure will be excluded from the protocol such as:
- Those with ferromagnetic metal in the cranial cavity or eye, e.g. aneurysm clip, implanted neural stimulator, cochlear implant, ocular foreign body.
- Those with an implanted cardiac pacemaker or auto-defibrillator.
- Those with an insulin pump.
- Those with an irremovable body piercing.
- Pregnant women
- Individuals with conditions that could pose a risk relating to the safety of the TMS procedure will be excluded from the protocol such as:
- Those with significant abnormality on neurological examination.
- Those with metal in the cranial cavity or eye, e.g. aneurysm clip, implanted neural stimulator, cochlear implant, ocular foreign body.
- Those with an implanted cardiac pacemaker or auto-defibrillator.
- Those with an insulin pump.
- Pregnant women
- Individuals with conditions that could compromise our interpretation of the TBS and fMRI results will be excluded such as:
- Those with significant abnormality on neurological examination.
- Those who have a significant psychiatric illness or have a history of psychiatric illness.
- Those using medication affecting the DA system, such as phenothiazine antihistamines (promethazine), antiemetics or decongestants within the last month.
Exclusion
Key Trial Info
Start Date :
December 7 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 23 2017
Estimated Enrollment :
174 Patients enrolled
Trial Details
Trial ID
NCT01260740
Start Date
December 7 2010
End Date
June 23 2017
Last Update
October 6 2017
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892