Status:
COMPLETED
Cross-sectional Characterization of Idiopathic Bronchiectasis
Lead Sponsor:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Infection
Bronchial Diseases
Eligibility:
All Genders
18-100 years
Brief Summary
Background: \- Bronchiectasis is a type of lung condition in which the lungs airways are abnormally stretched and widened. This stretching and widening makes it difficult for mucus and other substanc...
Detailed Description
The Genetic Disorders of Mucociliary Clearance Consortium (GDMCC) is comprised of 6 geographically-dispersed clinical research sites designed to study chronic disorders of the conducting airways assoc...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- The criteria for participants to enter the study mandates that each patient have received a standard (current clinical practice) diagnostic evaluation that includes a CT scan of the chest to document bronchiectasis, prior to enrolling in the Consortium study. To enter this protocol, adults must have bronchiectasis and meet the following criteria:
- Males or females, age greater than or equal to18 years
- Chronic cough
- An available CT of the chest (on a CD) that shows evidence of dilated airways fulfilling radiographic criteria for bronchiectasis in more than one lobe
- Ability to provide informed consent, including HIPAA consent
- EXCLUSION CRITERIA:
- A participant should not be in the study if they have not had a standard clinical evaluation to rule out other potential causes of chronic sino-pulmonary disease.
- Known diagnosis of cystic fibrosis with classic clinical presentation and elevated sweat chloride levels and/or two known disease-causing CFTR mutations
- History of tuberculosis or other known explanation for bronchiectasis, such as alpha 1-antitrypsin deficiency (ZZ or ZS), confirmed or probable PCD, inflammatory bowel disease, rheumatoid arthritis, Sjogren s syndrome, allergic bronchopulmonary aspergillosis, or documented primary or acquired immunodeficiency
- Current smoker or \> 10 pack-year history of tobacco use
- Prior solid organ transplant
Exclusion
Key Trial Info
Start Date :
April 26 2011
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
Estimated Enrollment :
275 Patients enrolled
Trial Details
Trial ID
NCT01264055
Start Date
April 26 2011
Last Update
January 5 2026
Active Locations (6)
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1
Stanford Medical Center
Stanford, California, United States, 94305
2
National Jewish Health
Denver, Colorado, United States, 80206
3
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
4
Washington University, St. Louis
St Louis, Missouri, United States, 63110