Status:
COMPLETED
Influence of Escitalopram on Fear Conditioning
Lead Sponsor:
Massachusetts General Hospital
Collaborating Sponsors:
Forest Laboratories
Conditions:
Fear Conditioning
Eligibility:
All Genders
18-75 years
Phase:
PHASE4
Brief Summary
The purpose of the study is to learn how differences in learning under mildly-stressful circumstances may be changed by taking an antidepressant medication. This medication is called Lexapro (Escitalo...
Eligibility Criteria
Inclusion
- Male or female outpatients 18 to 75 years of age
- Must have no current DSM-IV Axis I diagnosis as measured by the SCID (Structured Clinical Interview for DSM-IV-TR axis 1 disorders) with a trained study investigator. Past history of anxiety disorders, major depressive episodes or substance abuse disorders at least six months prior to baseline are not exclusionary.
Exclusion
- Patients will be excluded from entry into the study for current serious medical conditions or other conditions deemed likely to result in surgery or hospitalization.
- Patients with a history of trauma resulting in head injury related seizures, or with epilepsy (except a prior history of febrile seizures of infancy which are not exclusionary).
- Pregnant or lactating women or those of childbearing potential not using medically accepted forms of contraception will be excluded.
- Concurrent use of other antidepressants, benzodiazepines or antipsychotic medications.
- Patients with a history of hypersensitivity to escitalopram are excluded.
- Individuals must have discontinued MAO inhibitors more than 14 days before starting study drug.
- Additional contraindicated drugs during the study are pimozide, furazolidine, isocarboxazid, lazabemide, and St. John's Wort.
- Participants meeting DSM-IV or SCID criteria for a substance use disorder in the last six months other than nicotine dependence and those with a positive toxicology screen at baseline consistent with evidence of current substance abuse or dependence as determined by clinical interview.
- A lifetime history of Bipolar or any psychotic disorder is excluded.
- Current claustrophobia is exclusionary.
- Patients currently taking any narcotic will be excluded.
Key Trial Info
Start Date :
October 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2011
Estimated Enrollment :
65 Patients enrolled
Trial Details
Trial ID
NCT01398514
Start Date
October 1 2008
End Date
June 1 2011
Last Update
June 11 2014
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