Status:
COMPLETED
Cobalamin Absorption From Fortified Food
Lead Sponsor:
USDA, Western Human Nutrition Research Center
Conditions:
Vitamin B-12 Deficiency
Achlorhydria
Eligibility:
All Genders
60+ years
Phase:
NA
Brief Summary
To determine B12 bioavailability from 14C-B12 fortified bread in healthy subjects and in subjects with proton pump inhibitor induced achlorhydria.
Detailed Description
Cobalamin (vitamin B12) deficiency is highly prevalent in the US and worldwide. Deficiency is most common in the elderly, with an average prevalence ≈25% over age 60 y. About 40% of older persons with...
Eligibility Criteria
Inclusion
- good overall health
- normal absorptive capacity (controls) or with a serum B12 \<300 pg/mL and a pepsinogen I level \>100 μg/L (ACs).
- All subjects must be available to complete the protocol
Exclusion
- Any chronic health disorder
- Anemia of any kind
- Renal insufficiency
- excessive alcohol consumption
- Prior GI surgery
- Use of OTC or prescription drugs that interfere with B-12 absorption or metabolism
- Use of vitamin supplements
- Pregnancy or lactation
Key Trial Info
Start Date :
January 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2013
Estimated Enrollment :
6 Patients enrolled
Trial Details
Trial ID
NCT01399164
Start Date
January 1 2010
End Date
September 1 2013
Last Update
October 22 2013
Active Locations (1)
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1
Western Human Nutrition Center, University of California Davis
Davis, California, United States, 95616