Status:

TERMINATED

Ph I Ipilimumab Vemurafenib Combo in Patients With v-Raf Murine Sarcoma Viral Oncogene Homolog B1 (BRAF)

Lead Sponsor:

Bristol-Myers Squibb

Collaborating Sponsors:

Roche-Genentech

Conditions:

Melanoma

Eligibility:

All Genders

18+ years

Phase:

PHASE1

Brief Summary

Treatment of subjects who have metastatic melanoma that expresses an activated mutant form of the BRAF oncogene (V600E) with a combination of the specific BRAF inhibitor, Vemurafenib, and the Cytotoxi...

Eligibility Criteria

Inclusion

  • For more information regarding BMS clinical trial participation, please visit www.BMSStudyConnect.com.
  • Metastatic melanoma with activating V600 BRAF mutation
  • Measurable Tumor
  • Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) 0-1

Exclusion

  • Autoimmune disease
  • Active Brain Metastasis (must be stable after radiation for at least one month)
  • Prior therapy with immune stimulating agents

Key Trial Info

Start Date :

November 1 2011

Trial Type :

INTERVENTIONAL

Allocation :

ACTUAL

End Date :

December 1 2013

Estimated Enrollment :

18 Patients enrolled

Trial Details

Trial ID

NCT01400451

Start Date

November 1 2011

End Date

December 1 2013

Last Update

January 1 2015

Active Locations (4)

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Page 1 of 1 (4 locations)

1

University Of California Los Angeles

Los Angeles, California, United States, 90095

2

Dana Farber Cancer Institute

Boston, Massachusetts, United States, 02215

3

Dana Farber Cancer Inst

Boston, Massachusetts, United States, 02215

4

Memorial Sloan-Kettering Cancer Center

New York, New York, United States, 10065