Status:
COMPLETED
Stanford Universities: The Stanford HIV Aging Cohort
Lead Sponsor:
Stanford University
Conditions:
Acquired Immunodeficiency Syndrome
Eligibility:
All Genders
18+ years
Brief Summary
A research study to evaluate the effect of aging and HIV on neurocognitive dysfunction (declining ability to process information), physical frailty and heart disease. HIV-infected participants whose v...
Detailed Description
With advances in antiretroviral therapy, the life expectancy of HIV-infected individuals continues to improve with older individuals representing a rapidly growing proportion of those infected. Howeve...
Eligibility Criteria
Inclusion
- Subjects must have an HIV RNA level below the limit of quantification (e.g., \<75 copies, \<50 copies, or \<48 copies/mL, depending on the assay used) for at least 6 months excluding "blips" (e.g., a single measurement between 48-200 copies/mL preceded and followed by measurements below the limit of quantification) while on antiretroviral therapy.
Exclusion
- Completed treatment for any acute systemic infection (other than HIV-1) less than four weeks before study entry.
- Any active brain infection (except for HIV-1), brain neoplasm, or space-occupying brain lesion.
- Receipt of immunomodulating medication (e.g., corticosteroids, immunoglobulin, etc.) within four weeks of study entry.
- Any active psychiatric illness including schizophrenia, severe depression, or severe bipolar affective disorder that, in the opinion of the investigator, could confound the analysis of the neuropsychological test results.
- Active drug or alcohol abuse that, in the investigator's opinion, could prevent compliance with study procedures or confound the analysis of study endpoints.
- Unable to provide informed consent
Key Trial Info
Start Date :
December 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2015
Estimated Enrollment :
154 Patients enrolled
Trial Details
Trial ID
NCT01401348
Start Date
December 1 2010
End Date
December 1 2015
Last Update
March 17 2021
Active Locations (1)
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1
Stanford University School of Medicine
Stanford, California, United States, 94305