Status:
COMPLETED
Hydrogen Peroxide and Nitrite Reduction in Exhaled Breath Condensate of COPD Patients
Lead Sponsor:
Medical University of Lodz
Collaborating Sponsors:
Ministry of Science and Higher Education, Poland
Conditions:
Chronic Obstructive Pulmonary Disease
Eligibility:
All Genders
40-80 years
Phase:
PHASE1
Brief Summary
The aim of the study is to investigate the effect of inhaled apocynin on ROS (reactive oxygen species) and NOS (reactive nitrogen species) synthesis in 13 COPD patients. Effects of nebulized apocynin ...
Detailed Description
Apocynin reduced hydrogen peroxide concentration in exhaled breath condensate 60 and 120 minutes after apocynin nebulization comparing to placebo (0.43 μM vs. 0.59 μM and 0.41 μM vs. 0.58 μM respectiv...
Eligibility Criteria
Inclusion
- patients suffering from bronchial COPD (II and III stage)
- patients free of any medication few days before research
- patients had not suffered from any infectious diseases including upper respiratory tract infections for at least 3 months prior to the study
Exclusion
- Patients suffering from GOLD I stage
- patients taking medications few days before the study
- infectious diseases that had occurred 3 months or less before the study
Key Trial Info
Start Date :
October 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2011
Estimated Enrollment :
13 Patients enrolled
Trial Details
Trial ID
NCT01402297
Start Date
October 1 2010
End Date
April 1 2011
Last Update
July 26 2011
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