Status:
COMPLETED
2/2 D-Cycloserine Augmentation of CBT for Pediatric OCD
Lead Sponsor:
Massachusetts General Hospital
Collaborating Sponsors:
National Institute of Mental Health (NIMH)
University of South Florida
Conditions:
Obsessive-Compulsive Disorder
Eligibility:
All Genders
7-17 years
Phase:
NA
Brief Summary
The purpose of this study is to find out if D-Cycloserine (DCS), taken at the same time as a child gets cognitive behavioral therapy (CBT) can help children with pediatric obsessive-compulsive disorde...
Eligibility Criteria
Inclusion
- Clinical diagnosis of Obsessive-Compulsive Disorder as primary or co-primary diagnosis
- Score on CY-BOCS of 16 or greater
- Full Scale IQ greater than or equal to 85
- English speaking
Exclusion
- Receiving concurrent psychotherapy or a past adequate trial of CBT for OCD
- Initiation of an antidepressant within 12 weeks before study enrollment
- Initiation of an antipsychotic within 6 weeks before study enrollment
- No new alternative medications, nutritionals, or therapeutic diets within 6 weeks of study enrollment
- Any change in established psychotropic medication within 8 weeks before study enrollment (6 weeks for antipsychotic). Alternative medications must be stable for 6 weeks prior to baseline. Any medications must remain stable during treatment.
- Current clinically significant suicidality
- Suicidal behaviors within six months
- DSM-IV conduct disorder
- DSM-IV autism
- DSM-IV bipolar
- DSM-IV schizophrenia or schizo-affective disorders
- Substance abuse within the past six months
- Hoarding symptoms (due to difficulty implementing E/RP tasks)
- Weight less than 22.5k
- Epilepsy or renal insufficiency
- Current and/or past history of alcohol abuse (DCS is contraindicated)
- Pregnant or having unprotected sex (in females)
- Presence of a significant and/or unstable medical illness that might lead to hospitalization during the study
- Known DCS allergy
Key Trial Info
Start Date :
July 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2016
Estimated Enrollment :
206 Patients enrolled
Trial Details
Trial ID
NCT01404208
Start Date
July 1 2011
End Date
December 1 2016
Last Update
March 28 2017
Active Locations (1)
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1
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114