Status:
TERMINATED
Tight Hemodynamic Control in Patients Who Are Chronically on Metoprolol
Lead Sponsor:
University Health Network, Toronto
Collaborating Sponsors:
Baxter Healthcare Corporation
Conditions:
Vascular Disease
Hypertension
Eligibility:
All Genders
20-80 years
Phase:
PHASE4
Brief Summary
This study proposes to assess the effect of the standard of care, which is continuation of the pre op beta blocker dose into the post operative period compared to the administration of esmolol titrate...
Detailed Description
The number of high-risk patients undergoing non-cardiac surgery has increased continuously over the last two decades. There is a paucity of data exist about the bioavailability of postoperative admini...
Eligibility Criteria
Inclusion
- Patient inclusion criteria:
- Elective vascular surgery
- Any of the following co morbidities
- Diabetes
- Angina
- Congestive heart failure
- A serum creatinine above 176 mmol/l
- All patients must be on stable dose of oral metoprolol (≥ 30 days)
- Age ≥ 20 years and ≤ 80 years
- Written informed consent to participate to the study
- Patient exclusion criteria:
- Inability to understand the study protocol
- Prior gastric surgery or small bowel resection
- Pacemaker ( since it precludes the measurement of ST changes)
- Malabsorption syndromes
- Body Mass Index \< 18 and \> 35
- Any patient with suspected of diagnosed Cerebral vascular disease. (We chose to exclude CVA patients due to the ongoing controversy about the increased incidence of stroke in patients have surgery and who are taking beta-blockers.)
Exclusion
Key Trial Info
Start Date :
April 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2013
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT01404767
Start Date
April 1 2011
End Date
December 1 2013
Last Update
April 21 2015
Active Locations (1)
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1
University Heatlh Network, Toronto General Hopsital
Toronto, Ontario, Canada, M5G 2C4