Status:
COMPLETED
Evaluation of Brain Damage Resulting From Carotid Endarterectomy With Xenon Anesthesia
Lead Sponsor:
Centre Hospitalier Universitaire de Nīmes
Conditions:
Carotid Endarterectomy
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The objective of this study is to show that, in patients undergoing carotid endarterectomy, brain damage, assessed by the determination of S100B before removing the clamp, is less severe with a balanc...
Eligibility Criteria
Inclusion
- The patient must have given his/her informed and signed consent
- The patient must be insured or beneficiary of a health insurance plan
- Patients with American Society of Anesthesiology (ASA) scores of 1 to 4
- Patient schelduled for carotid endarterectomy
Exclusion
- The patient is participating in another study
- The patient is in an exclusion period determined by a previous study
- The patient is under judicial protection, under tutorship or curatorship
- The patient refuses to sign the consent
- It is impossible to correctly inform the patient
- The patient is pregnant
- The patient is breastfeeding
- The patient has a contra-indication for a treatment necessary for this study
- The endarterectomy does not require a shunt
- ASA score of 5
- Patient presenting with symptomatic gastric-oesophagien reflux
- Patient has neuro-endocrine cancer
- Patient has hypersensivity to one of the following substances: propofol, remifentanil, celocurine, cisatracurium, rocuronium, senon, paracetamol, tramadol
- Patient suffering from obstructive respiratory insufficiency (chronic obstructive pulmonary disease, asthma)
- Patient with coronary disease with severely altered cardiac function
- High intracranial pressure
- Patient requiring high concentrations of oxygen (SpO2 \< 92% normal air)
- Patient with neuro-sensorial deficit that, in the absence of a prothesis, prevents reading, writing, or responding to simple orders
- Patient suffering from myopathy or recent rhabdomyolysis
- Patient with psychiatric pathology or chronic alcohol consumption or consumption of another substance that interferes with understanding
- Lack of contraception for women of child-bearing age
- History of or suspected malignant hyperthermia
- Patients with liver damage, jaundice, unexplained fever or eosinophilia after administration of a halogenated anesthetic
- Patient has undergone a recent multiple trauma (\<1 month)
- Patient who received general anesthesia within the past 7 days
Key Trial Info
Start Date :
April 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2015
Estimated Enrollment :
86 Patients enrolled
Trial Details
Trial ID
NCT01404819
Start Date
April 1 2012
End Date
February 1 2015
Last Update
March 27 2015
Active Locations (1)
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1
Centre Hospitalier Universitaire de Nîmes
Nîmes, Gard, France, 30029