Status:
WITHDRAWN
Tacrine Effects on Cocaine Self-Administration and Pharmacokinetics
Lead Sponsor:
Midwest Biomedical Research Foundation
Conditions:
Cocaine Dependence
Eligibility:
All Genders
21-50 years
Phase:
PHASE2
Brief Summary
No medications are currently available for treatment of psychostimulant addiction, a compulsive preoccupation with use of cocaine and related compounds. Tacrine, a medication that is currently prescri...
Detailed Description
Background Reinforcing effects of cocaine are believed to arise through release of dopamine (DA) at the nucleus accumbens by neurons in the ventral tegmental area. Activation of cholinergic receptors ...
Eligibility Criteria
Inclusion
- Meets DSM-IV-TR criteria for cocaine abuse or dependence, with at least one cocaine-positive urine specimen within the six weeks prior to enrollment.
- Has used cocaine for a duration of at least 6 months, with at least weekly use during the last 30 days by a rapid route of administration (either smoked or intravenous injection).
- Is male or female, between 21 and 50 years old.
Exclusion
- Has a history of a medical adverse reaction to cocaine or other psychostimulants, including loss of consciousness, chest pain, cardiac ischemia, or seizure.
- Has any current Axis I psychiatric disorder other than drug abuse or dependence.
- Meets DSM-IV-TR criteria for dependence on opiates, benzodiazepines, alcohol, or other sedative-hypnotics.
Key Trial Info
Start Date :
October 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2013
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT01406522
Start Date
October 1 2012
End Date
November 1 2013
Last Update
December 18 2013
Active Locations (1)
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1
Kansas City VA Medical Center
Kansas City, Missouri, United States, 64128