Status:
COMPLETED
Evaluation of Fructose Ingestion and the Renin Angiotensin System in Humans
Lead Sponsor:
University of Calgary
Conditions:
Chronic Kidney Disease
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Fructose is an ingredient that is added to many of our foods. It is a cheaper, sweeter additive that can be found in everything from soda pop to yogurt to granola bars. In the last few years a signifi...
Detailed Description
PRIMARY AIM: To examine whether the physiologic and molecular responses to Angiotensin II (AngII) challenge differ in response to fructose intake as assessed by two independent means: 1. The renal an...
Eligibility Criteria
Inclusion
- age≥18 years,
- able to comprehend study and comply with high-salt diet
- kidney disease (on the approval of their nephrologist)
- on an oral birth control pill and non oral birth control and those not on birth control
Exclusion
- cardiovascular disease (symptoms consistent with myocardial ischemia, previously documented myocardial ischemia, cardiac arrhythmias or valve abnormalities, or abnormal ECG at screening)
- cerebrovascular disease (transient ischemic attacks or stroke)
- hypertension (BP\>140/90 or use of antihypertensive medications)
- diabetes mellitus (defined by history, use of hypoglycemic agents or a fasting glucose \>7mmol/L)
- hyperlipidemia (LDL \>4.5mmol/L or use of lipid-lowering agents)
- pregnancy
Key Trial Info
Start Date :
July 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2021
Estimated Enrollment :
64 Patients enrolled
Trial Details
Trial ID
NCT01407627
Start Date
July 1 2011
End Date
May 1 2021
Last Update
May 19 2022
Active Locations (1)
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1
University of Calgary
Calgary, Alberta, Canada, T2N 2T9