Status:
COMPLETED
Comparison Between Epidural and Bilateral Paravertebral Blocks in Liver Resection
Lead Sponsor:
University of Pittsburgh
Conditions:
Liver Disease
Pain
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This prospective, randomized study is intended to assess the efficacy and safety of bilateral continuous paravertebral blocks compared to continuous epidural block for open liver resection. Hypotheses...
Detailed Description
Background: A number of studies evaluating unilateral continuous paravertebral block demonstrate equal or superior analgesia when compared to epidural analgesia for postoperative pain control (1-7). A...
Eligibility Criteria
Inclusion
- American Society of Anesthesiologists physical status (ASAPS) I to III patients aged over 18 years and scheduled to undergo elective open liver resection at UPMC Presbyterian/Montefiore Hospital will be screened for enrollment in the study. One hundred (100) patients will be enrolled in this study with equal numbers (n = 50) in each arm of the trial. In order to avoid skewed sex difference between the two groups, the sex will be allocated.
Exclusion
- non elective surgery,
- ASAPS IV or greater,
- age younger than 18 years,
- any contraindication to the placement of an epidural catheter or bilateral paravertebral catheters
- chronic pain conditions
- preoperative opioid use
- coagulation abnormalities or patients who are expected to be on therapeutic anticoagulants postoperatively
- allergy to any of the drugs/agents used our study protocol
- preoperative chronic renal dysfunction, who requires renal replacement therapy or serum creatinine greater than 1.4 mg/dL
- altered mental status (not oriented to place, person, or time),
- any comorbid conditions that, in the judgment of the consulting surgeon or anesthesiologist, would proscribe the patient from any aspect of the study, -
- inability to provide adequate informed consent
- refusal to participate in the study.
Key Trial Info
Start Date :
August 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2014
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT01407666
Start Date
August 1 2010
End Date
November 1 2014
Last Update
December 3 2014
Active Locations (1)
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1
University of Pittsburgh School of Medicine
Pittsburgh, Pennsylvania, United States, 15213